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(2S,3S,4R)-4-Amino-3-hydroxy-2-methylpentanoic acid. Enantioselective synthesis of an amino acid constituent of bleomycin.

✍ Scribed by Robert M. DiPardo; Mark G. Bock


Publisher
Elsevier Science
Year
1983
Tongue
French
Weight
189 KB
Volume
24
Category
Article
ISSN
0040-4039

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✦ Synopsis


2S,3S,4R)-4-Amino-3-hydroxy-2-methylpentanoic acid has been synthesized through acylation of a chiral enolate and subsequent stereoselective reduction.


πŸ“œ SIMILAR VOLUMES


Synthesis of (2S,3R)-3-amino-2-hydroxyde
✍ Arounarith Tuch; MichΓ¨le SaniΓ¨re; Yves Le Merrer; Jean-Claude Depezay πŸ“‚ Article πŸ“… 1996 πŸ› Elsevier Science 🌐 English βš– 528 KB

Taking advantage of the high functionality of an enantiopure protected syn-2R-amino-l,3,4-triol derivative, easily available on a multigram scale from Disoascorbic acid, several biologically active compounds have been synthesized such as the (2S,3R)-3-amino-2-hydroxydecanoic acid (AHDA), the N-termi