2S,3S,4R)-4-Amino-3-hydroxy-2-methylpentanoic acid has been synthesized through acylation of a chiral enolate and subsequent stereoselective reduction.
Stereoselective synthesis of (2s,3s,4r)-4-amino-3-hydroxy-2-methyl-pentanoic acid, an amino acid constituent of bleomycin, by aldold condensation)
β Scribed by Masatoshi Narita; Masami Otsuka; Susumu Kobayashi; Masaji Ohno; Yoji Umezawa; Hajime Morishima; Sei-ichi Saito; Tomohisa Takita; Hamao Umezawa
- Publisher
- Elsevier Science
- Year
- 1982
- Tongue
- French
- Weight
- 243 KB
- Volume
- 23
- Category
- Article
- ISSN
- 0040-4039
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Taking advantage of the high functionality of an enantiopure protected syn-2R-amino-l,3,4-triol derivative, easily available on a multigram scale from Disoascorbic acid, several biologically active compounds have been synthesized such as the (2S,3R)-3-amino-2-hydroxydecanoic acid (AHDA), the N-termi
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