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Synthetic studies on polyoxypeptins: stereoselective synthesis of (2S,3R)-3-hydroxy-3-methylproline using SmI2-mediated cyclization

✍ Scribed by Kazuishi Makino; Ai Kondoh; Yasumasa Hamada

Publisher: Elsevier Science
Year: 2002
Tongue: French
Weight: 75 KB
Volume: 43
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(02)00833-x

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✦ Synopsis

Stereoselective synthesis of (2S,3R)-3-hydroxy-3-methylproline (3), a component of polyoxypeptins, has been achieved by use of SmI 2 -mediated diastereoselective cyclization reaction as a key step.

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