Enantioselective reduction of diethyl 2-oxoalkylphosphonates by baker's yeast
✍ Scribed by Ewa Żymańczyk-Duda; Barbara Lejczak; Pawel Kafarski; Jean Grimaud; Peter Fischer
- Publisher
- Elsevier Science
- Year
- 1995
- Tongue
- French
- Weight
- 353 KB
- Volume
- 51
- Category
- Article
- ISSN
- 0040-4020
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## Abstract Bioreduction of 3‐substituted‐2‐oxoal‐kanephosphonates by baker's yeast afforded 3‐substituted‐2‐hydroxy‐alkanephosphonates in moderate to good yields and ee value. These compounds could serve as useful chirons for the stereoselective synthesis of phosphorus analogs of biologically acti
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## Abstract Dialkyl 4‐(dialkoxyphosphoryl)‐3‐oxobutanoates (**__1__**), upon yeast‐mediated bioreduction, afforded chiral dialkyl 4‐(dialkoxyphosphoryl)‐3‐hydroxybutanoates (**__2__**) in moderate to good yields and ee values. Significant improvement was reported for the preparation of dialkyl 4‐(d