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Enantioselective reduction of dialkyl 4-(dialkoxyphosphoryl)-3-oxobutanoates by baker's yeast

✍ Scribed by Chengye Yuan; Ke Wang; Jinfeng Li; Zuyi Li

Publisher
John Wiley and Sons
Year
2002
Tongue
English
Weight
120 KB
Volume
13
Category
Article
ISSN
1042-7163

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✦ Synopsis

Abstract

Dialkyl 4‐(dialkoxyphosphoryl)‐3‐oxobutanoates (1), upon yeast‐mediated bioreduction, afforded chiral dialkyl 4‐(dialkoxyphosphoryl)‐3‐hydroxybutanoates (2) in moderate to good yields and ee values. Significant improvement was reported for the preparation of dialkyl 4‐(dialkoxyphosphoryl)‐3‐oxobutanoates (1), the key substrates of this bioreductive conversion. © 2002 Wiley Periodicals, Inc. Heteroatom Chem 13:153–156, 2002; Published online in Wiley Interscience (www.interscience.wiley.com). DOI 10.1002/hc.10011

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