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Enantioselective reduction of 2-keto-3-haloalkane phosphonates by baker's yeast

✍ Scribed by Cheng-ye Yuan; Ke Wang; Zu-yi Li

Publisher
John Wiley and Sons
Year
2001
Tongue
English
Weight
159 KB
Volume
12
Category
Article
ISSN
1042-7163

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✦ Synopsis

Abstract

Bioreduction of 3‐substituted‐2‐oxoal‐kanephosphonates by baker's yeast afforded 3‐substituted‐2‐hydroxy‐alkanephosphonates in moderate to good yields and ee value. These compounds could serve as useful chirons for the stereoselective synthesis of phosphorus analogs of biologically active molecules including R‐(—)‐3‐trimethylammonium‐2‐hydroxypropanoic acid and R‐(—)‐3‐ trimethylammonium‐2‐hydroxypropanoic acid. © 2001 John Wiley & Sons, Inc. Heteroatom Chem 12:551–556, 2001

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Enantioselective reduction of dialkyl 4-
Enantioselective reduction of dialkyl 4-(dialkoxyphosphoryl)-3-oxobutanoates by baker's yeast
✍ Chengye Yuan; Ke Wang; Jinfeng Li; Zuyi Li 📂 Article 📅 2002 🏛 John Wiley and Sons 🌐 English ⚖ 120 KB

## Abstract Dialkyl 4‐(dialkoxyphosphoryl)‐3‐oxobutanoates (**__1__**), upon yeast‐mediated bioreduction, afforded chiral dialkyl 4‐(dialkoxyphosphoryl)‐3‐hydroxybutanoates (**__2__**) in moderate to good yields and ee values. Significant improvement was reported for the preparation of dialkyl 4‐(d