Enantioselective production of 3-hydroxy metabolites of tibolone by yeast reduction
✍ Scribed by Diego Romano; Valerio Ferrario; Diego Mora; Roberto Lenna; Francesco Molinari
- Book ID
- 116892104
- Publisher
- Elsevier Science
- Year
- 2008
- Tongue
- English
- Weight
- 395 KB
- Volume
- 73
- Category
- Article
- ISSN
- 0039-128X
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📜 SIMILAR VOLUMES
Stereoselective preparation of the 3-hydroxy metabolites of tibolone is easily accomplished by diastereoselective Candida antarctica lipase B-catalyzed transformations of 3a-and 3b-alcohols or acetates mixtures in organic solvents, in suitable amounts for biological studies.
## Abstract Bioreduction of 3‐substituted‐2‐oxoal‐kanephosphonates by baker's yeast afforded 3‐substituted‐2‐hydroxy‐alkanephosphonates in moderate to good yields and ee value. These compounds could serve as useful chirons for the stereoselective synthesis of phosphorus analogs of biologically acti
## Abstract Dialkyl 4‐(dialkoxyphosphoryl)‐3‐oxobutanoates (**__1__**), upon yeast‐mediated bioreduction, afforded chiral dialkyl 4‐(dialkoxyphosphoryl)‐3‐hydroxybutanoates (**__2__**) in moderate to good yields and ee values. Significant improvement was reported for the preparation of dialkyl 4‐(d