𝔖 Bobbio Scriptorium
✦   LIBER   ✦

A practical chemoenzymatic approach to the synthesis of 3-hydroxy metabolites of tibolone

✍ Scribed by Patrizia Ferraboschi; Diego Colombo; Shahrzad Reza-Elahi

Book ID
104359528
Publisher
Elsevier Science
Year
2002
Tongue
English
Weight
107 KB
Volume
13
Category
Article
ISSN
0957-4166

No coin nor oath required. For personal study only.

✦ Synopsis

Stereoselective preparation of the 3-hydroxy metabolites of tibolone is easily accomplished by diastereoselective Candida antarctica lipase B-catalyzed transformations of 3a-and 3b-alcohols or acetates mixtures in organic solvents, in suitable amounts for biological studies.

πŸ“œ SIMILAR VOLUMES

Stereoselective Convergent Synthesis of
Stereoselective Convergent Synthesis of 24,25-Dihydroxyvitamin D3 Metabolites: A Practical Approach
✍ JosΓ© PΓ©rez Sestelo; IvΓ‘n Cornella; Olga de UΓ±a; Antonio MouriΓ±o; Luis A. Sarande πŸ“‚ Article πŸ“… 2002 πŸ› John Wiley and Sons 🌐 English βš– 143 KB πŸ‘ 1 views

Vitamin D3 active metabolites 24R,25-(OH)2-D3, 24S,25-(OH)2-D3, and 1 alpha, 24R,25-(OH)3-D3 were synthesized by a convergent and stereoselective approach. In the synthetic route, the stereogenic center at C-24 was generated through ultrasonically induced aqueous conjugate addition of iodide 6 to Se

Practical chemoenzymatic synthesis of a
Practical chemoenzymatic synthesis of a 3-pyridylethanolamino Ξ²3 adrenergic receptor agonist
✍ John Y.L Chung; Guo-Jie Ho; Michel Chartrain; Chris Roberge; Dalian Zhao; John L πŸ“‚ Article πŸ“… 1999 πŸ› Elsevier Science 🌐 French βš– 293 KB

A chemoenzymatic synthesis of 133 agonist 1 suitable for large scale preparation is described. The key chiral 3pyridylethanolamine intermediate (R)-7 was prepared via an improved Neber rearrangement and a yeast-mediated asymmetric reduction. The tetrazolone fragment of the molecule was constructed v