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Enantioselective Michael Additions of Nitromethane by a Catalytic Double Activation Method Using Chiral Lewis Acid and Achiral Amine Catalysts

โœ Scribed by Itoh, Kennosuke; Kanemasa, Shuji


Book ID
119978792
Publisher
American Chemical Society
Year
2002
Tongue
English
Weight
59 KB
Volume
124
Category
Article
ISSN
0002-7863

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Enantioselective Michael addition reacti
โœ Kennosuke Itoh; Yoji Oderaotoshi; Shuji Kanemasa ๐Ÿ“‚ Article ๐Ÿ“… 2003 ๐Ÿ› Elsevier Science ๐ŸŒ English โš– 207 KB

Reactions of malononitrile with 3-(2-alkenoyl)-2-oxazolidinones or 1-(2-alkenoyl)-4-bromo-3,5-dimethylpyrazoles can be doubly activated by the use of catalytic amounts (10 mol% each) of both (R,R)-DBFOX/Phโ€ขNi(ClO 4 ) 2 โ€ข3H 2 O and amines, to give the Michael adducts in high chemical yields with sati