Enantioselective hydrogenation of β-keto esters catalyzed by chiral binaphthylbisphosphine ruthenium complexes
✍ Scribed by V. A. Pavlov; E. V. Starodubtseva; M. G. Vinogradov; V. A. Ferapontov; O. R. Malyshev; G. L. Heise
- Book ID
- 105595915
- Publisher
- Springer
- Year
- 2000
- Tongue
- English
- Weight
- 273 KB
- Volume
- 49
- Category
- Article
- ISSN
- 1573-9171
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The diastereoselective catalytic hydrogenation of β-keto sulfoxides in the presence of ruthenium complexes was studied. Optically pure β-keto sulfoxides were hydrogenated in the presence of achiral catalysts leading to moderate yields and stereoselectivities. Using chiral ruthenium catalysts such as
Asymmetric hydrogenation of keto esters using a BisP\*-RuBr\_, catalyst is reported. High enantioselectivities up to 98% were achieved in the hydrogenation of [3-keto esters.
Enantioselective Hydrogenation of β-Keto Esters Catalyzed by P-Chiral Bis(dialkylphosphino)ethanes-Ru(II). -The asymmetric hydrogenation of β-keto esters or related compounds to the corresponding secondary alcohols is readily achieved with a homogeneous Ru-catalyst based on a P-chiral bis(dialkylph