Enantioselective hydrogenation catalyzed by highly active rhodium complexes of chiral phosphites with atropisomeric moieties

✍ Scribed by Ildikó Gergely; Csaba Hegedüs; Henrik Gulyás; Áron Szöllősy; Axel Monsees; Thomas Riermeier; József Bakos

• Publisher: Elsevier Science
• Year: 2003
• Tongue: English
• Weight: 133 KB
• Volume: 14
• Category: Article
• ISSN: 0957-4166
• DOI: 10.1016/s0957-4166(03)00131-9

✦ Synopsis

Excellent ee's and extremely high activities are obtained in the rhodium-catalyzed hydrogenation of dimethyl itaconate using simple and readily available H 8 -BINOL based monodentate phosphites. The hydrogenation proceeds efficiently even at a substrate concentration of 5.263 mol L -1 and at a substrate to catalyst ratio (S/C) of 40,000 to give the product in 95.1% yield with up to 96.9% ee.