Highly enantioselective hydrogenation of enamides catalyzed by rhodium–monodentate phosphoramidite complex

✍ Scribed by Xian Jia; Rongwei Guo; Xingshu Li; Xinsheng Yao; Albert S.C Chan

• Publisher: Elsevier Science
• Year: 2002
• Tongue: French
• Weight: 63 KB
• Volume: 43
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(02)01142-5

✦ Synopsis

The monodentate phosphoramidite ligand monophos was used in the Rh-catalyzed asymmetric hydrogenation of enamides to give high enantioselectivities (up to 96% ee).