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Enantioselective and sensitive determination of carvedilol in human plasma using chiral stationary-phase column and reverse-phase liquid chromatography with tandem mass spectrometry

✍ Scribed by Jiang, Juanjuan; Tian, Lei; Huang, Yiling; Yan, Yan; Li, Yishi


Book ID
122322354
Publisher
Elsevier Science
Year
2014
Tongue
English
Weight
897 KB
Volume
960
Category
Article
ISSN
1873-376X

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## Abstract A sensitive, specific and rapid liquid chromatography–mass spectrometry (LC‐MS/MS) method has been developed and validated for enantioselective determination of darusentan enantiomers, orally active potent endothelin‐A receptor antagonist, in rat plasma. The plasma samples were pretreat