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Analysis of carvedilol enantiomers in human plasma using chiral stationary phase column and liquid chromatography with tandem mass spectrometry

✍ Scribed by Josiane Cristófani Poggi; Flávia Garcez Da Silva; Eduardo Barbosa Coelho; Maria Paula Marques; Carlo Bertucci; Vera Lucia Lanchote

Book ID
112049425
Publisher
John Wiley and Sons
Year
2012
Tongue
English
Weight
869 KB
Volume
24
Category
Article
ISSN
0899-0042

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## Abstract A sensitive, specific and rapid liquid chromatography–mass spectrometry (LC‐MS/MS) method has been developed and validated for enantioselective determination of darusentan enantiomers, orally active potent endothelin‐A receptor antagonist, in rat plasma. The plasma samples were pretreat