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Analysis of ibuprofen enantiomers in rat plasma by liquid chromatography with tandem mass spectrometry

✍ Scribed by Cardoso, Juciane Lauren Cavalcanti; Lanchote, Vera Lucia; Pereira, Maria Paula Marques; de Moraes, Natália Valadares; Lepera, José Salvador

Book ID: 121674173
Publisher: John Wiley and Sons
Year: 2014
Tongue: English
Weight: 165 KB
Volume: 37
Category: Article
ISSN: 1615-9306
DOI: 10.1002/jssc.201301184

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## Abstract A sensitive, specific and rapid liquid chromatography–mass spectrometry (LC‐MS/MS) method has been developed and validated for enantioselective determination of darusentan enantiomers, orally active potent endothelin‐A receptor antagonist, in rat plasma. The plasma samples were pretreat