Determination of (+)- and (−)-nilvadipine in human plasma using chiral stationary-phase liquid chromatography and gas chromatography-mass spectrometry, and a preliminary pharmacokinetic study in humans
✍ Scribed by Yoji Tokuma; Tomoichi Fujiwara; Hideyo Noguchi
- Publisher
- John Wiley and Sons
- Year
- 1987
- Tongue
- English
- Weight
- 433 KB
- Volume
- 76
- Category
- Article
- ISSN
- 0022-3549
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
rac-Isradipine is a dihydropyridine type calcium antagonist. Its calcium entry blocking effect is due primarily to the (+)-(S)-enantiomer. This study describes a sensitive enantioselective method for the determination of isradipine in human serum. Following alkaline extraction into hexane, the enant
## Abstract A selective and sensitive method employing high‐performance liquid chromatography–electrospray ionization mass spectrometry was developed and validated for the determination of mitiglinide in human plasma.With gliclazide as the internal standard, mitiglinide was extracted from plasma wi