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Determination of felodipine enantiomers using chiral stationary phase liquid chromatography and gas chromatography/mass spectrometry, and the study of their pharmacokinetic profiles in human and dog

✍ Scribed by Takashi Sakamoto; Yumi Ohtake; Motofumi Itoh; Shigeru Tabata; Takeo Kuriki; Kazuo Uno


Publisher
John Wiley and Sons
Year
1993
Tongue
English
Weight
430 KB
Volume
7
Category
Article
ISSN
0269-3879

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rac-Isradipine is a dihydropyridine type calcium antagonist. Its calcium entry blocking effect is due primarily to the (+)-(S)-enantiomer. This study describes a sensitive enantioselective method for the determination of isradipine in human serum. Following alkaline extraction into hexane, the enant