Enantiopure N -Acyldihydropyridones as Synthetic Intermediates: Asymmetric Synthesis of (−)-Septicine and (−)-Tylophorine
✍ Scribed by Comins, Daniel L.; Chen, Xinghai; Morgan, Lawrence A.
- Book ID
- 126662494
- Publisher
- American Chemical Society
- Year
- 1997
- Tongue
- English
- Weight
- 148 KB
- Volume
- 62
- Category
- Article
- ISSN
- 0022-3263
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📜 SIMILAR VOLUMES
## The mdohzrdme alkalords (+)-septlane and (k)-tylophonne were prepared from N-acyldLhydropyndone 7 tn five and SW steps, respectively Recently we hdve been studying the synthesis and synthetic utility of N-acyl-2,3-dlhydm-4-pyndoneq These highly functlonJlzed heterocycles are conveniently prepar
The trans-pip&dine alkaloid, (-)-solenopsin A. was prepared in seven steps from readily available 4-~haxy-3\_(niiropropyrsilyllpyrfdin in 43% overall yield. The addition of organ~tallics to chiral 1-acylpyridinium salt 1 gives N-acyl-2-alkyl-23&hydta~4pyridones 2 with high diastereoselectivity.\*~ T