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Enantiopure N-Acyldihydropyridones as Synthetic Intermediates: The First Asymmetric Synthesis of trans-Decahydroquinoline Alkaloid (+)-219A

โœ Scribed by Comins, Daniel L.; Dehghani, Ali


Book ID
127113547
Publisher
American Chemical Society
Year
1995
Tongue
English
Weight
230 KB
Volume
60
Category
Article
ISSN
0022-3263

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Enantiopure N-acyldihydropyridones as sy
โœ Daniel L. Comins; Nezha Radi Benjelloun ๐Ÿ“‚ Article ๐Ÿ“… 1994 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 259 KB

The trans-pip&dine alkaloid, (-)-solenopsin A. was prepared in seven steps from readily available 4-~haxy-3\_(niiropropyrsilyllpyrfdin in 43% overall yield. The addition of organ~tallics to chiral 1-acylpyridinium salt 1 gives N-acyl-2-alkyl-23&hydta~4pyridones 2 with high diastereoselectivity.\*~ T