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Enantiopure N -Acyldihydropyridones as Synthetic Intermediates: Asymmetric Syntheses of Indolizidine Alkaloids (−)-205A, (−)-207A, and (−)-235B

✍ Scribed by Comins, Daniel L.; LaMunyon, Donald H.; Chen, Xinghai


Book ID
127318590
Publisher
American Chemical Society
Year
1997
Tongue
English
Weight
202 KB
Volume
62
Category
Article
ISSN
0022-3263

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Enantiopure N-acyldihydropyridones as sy
✍ Daniel L. Comins; Nezha Radi Benjelloun 📂 Article 📅 1994 🏛 Elsevier Science 🌐 French ⚖ 259 KB

The trans-pip&dine alkaloid, (-)-solenopsin A. was prepared in seven steps from readily available 4-~haxy-3\_(niiropropyrsilyllpyrfdin in 43% overall yield. The addition of organ~tallics to chiral 1-acylpyridinium salt 1 gives N-acyl-2-alkyl-23&hydta~4pyridones 2 with high diastereoselectivity.\*~ T