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Enantiomeric LC separation of calcium antagonists on protein-based chiral stationary phases

✍ Scribed by Dr. Ersilia De Lorenzi; Anthony F. Fell; Alan L. Holmes; Gabriele Caccialanza; Gabriella Massolini; Carlo Gandini; Mikes Kitsos; Carolina Ponci

Publisher
John Wiley and Sons
Year
1993
Tongue
English
Weight
343 KB
Volume
5
Category
Article
ISSN
0899-0042

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✦ Synopsis

Three chiral calcium antagonist drugs, bepridil and two dihydropyridine derivatives (nicardipine and REC 15123751, have been successfully separated within short retention times using either the a,-acid glycoprotein chiral stationary phase (Chiral AGP) or the ovomucoid column (Ultron ES-OW). Aqueous buffer at defined pH is modified by the addition of an organic component (propan-2-01, acetonitrile, ethanol) in order to modulate the retention properties of each system. The influence of pH and percentage of organic modifier on retention, selectivity, resolution, and column performance are discussed for bepridil analyzed on Chiral AGP and for the two dihydropyridines (nicardipine and REC 1512375) analyzed on Ultron E S -O W stationary phases.

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