Enantioselective separation of enantiomeric amides on three amylose-based chiral stationary phases: Effects of backbone and carbamate side chain chiralities
✍ Scribed by Tristan D. Booth; W. John Lough; Mansoor Saeed; Terrence A.G. Noctor; Irving W. Wainer
- Publisher
- John Wiley and Sons
- Year
- 1997
- Tongue
- English
- Weight
- 167 KB
- Volume
- 9
- Category
- Article
- ISSN
- 0899-0042
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✦ Synopsis
A series of enantiomeric amides have been chromatographed on three amylose-based chiral stationary phases (CSPs): amylose tris(3,5-dimethylphenylcarbamate) (AD-CSP), amylose tris(S-phenylethylcarbamate) (AS-CSP), and amylose tris(Rphenylethyl-carbamate) (AR-CSP). The relative retentions and enantioselectives of the solutes on the three CSPs were compared and basic structure-retention relationships developed to describe the chromatographic results. The data indicate that for these solutes the observed elution order was a function of the chirality of the amylose backbone, while the magnitude of the enantioselective separations was affected by the chirality of the carbamate side chain.