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Embryonic antigen expression in chemically induced rat hepatomas and sarcomas

✍ Scribed by R. W. Baldwin; Dorothy Glaves; B. M. Vose

Publisher
John Wiley and Sons
Year
1972
Tongue
French
Weight
677 KB
Volume
10
Category
Article
ISSN
0020-7136

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✦ Synopsis

Abstract

Embryonic antigens were detected at the surface of carcinogen‐induced rat hepatoma and sarcoma cells by their reactivity in membrane immunofluorescence tests with sera from multiparous rats. These sera also showed complement‐dependent cytotoxicity for plated target tumour cells, and lymph‐node cells from multiparous rats were similarly cytotoxic when compared with the effects of cells from normal virgin age‐matched controls. These embryonic antigens could be demonstrated on embryonic cells but not on cultured normal adult rat liver cells or lung fibroblasts. The tumour‐associated embryonic antigens were shown to be common to both tumour types and so differ from the individually distinct antigens associated with these carcinogen‐induced tumours which play a major role in immune rejection responses.

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