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Elucidation of the catalytic mechanism of carbonic anhydrase

โœ Scribed by Riepe, Mary E.; Wang, Jui Hsin.


Book ID
126072720
Publisher
American Chemical Society
Year
1967
Tongue
English
Weight
147 KB
Volume
89
Category
Article
ISSN
0002-7863

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A new model for catalysis of human carbonic anhydrase II is suggested. The model is based on the X-ray structure of the hydrogen bond network in the catalytic site. The outer part of the network is proposed to adjust the pK a of the catalytic site to the experimentally observed value of about 7. The