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Electrochemical Study of Gliclazide and Its Complexation with β-Cyclodextrin

✍ Scribed by Abd-Elgawad Radi; Shimaa Eissa

Publisher
John Wiley and Sons
Year
2010
Tongue
English
Weight
288 KB
Volume
22
Category
Article
ISSN
1040-0397

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✦ Synopsis

Abstract

The electrochemical oxidation of gliclazide has been investigated at glassy carbon electrode in phosphate buffer solutions over the pH range 2.7–11.8 using cyclic and differential pulse voltammetry (DPV). Gliclazide exhibited one anodic peak in the pH range of 2.7–6.3 and a second peak was produced above pH 6.3. The oxidation processes have been shown to be irreversible and diffusion controlled. The formation of an inclusion complex of gliclazide with β‐cyclodextrin (β‐CD) has been investigated by cyclic and differential pulse voltammetry. A phase solubility study with spectrophotometric detection has been also applied. The stability constant of the complex was determined to be 839 and 360 M^−1^ using the differential pulse voltammetric method and the phase solubility method, respectively.

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