1H NMR spectroscopic study of complexation of citalopram with β-cyclodextrin in aqueous solution

✍ Scribed by Syed Mashhood Ali; Arti Maheshwari; Bharat Inder Fozdar

• Publisher: John Wiley and Sons
• Year: 2007
• Tongue: English
• Weight: 164 KB
• Volume: 45
• Category: Article
• ISSN: 0749-1581
• DOI: 10.1002/mrc.1958

✦ Synopsis

Abstract

^1^H NMR spectroscopic study of citalopram (CT) in the absence as well as in the presence of β‐cyclodextrin (β‐CD) in aqueous solution revealed the formation of four 1:1 β‐CD–CT inclusion complexes. The stoichiometry of the complexes was determined by the continuous variation (Job) method, which was further confirmed by Scott's method. The binding constants (K~R~ and K~R, S~) were calculated using Scott's method. The structures of all the complexes have been proposed as shown in the diagrams. All the CT proton resonances showed splitting in the presence of β‐CD, owing to chiral discrimination by the β‐CD, between the two enantiomers. The chiral discrimination appears to be due to different modes of binding of the R‐ and S‐CT in the complexes involving a CN‐containing aromatic ring. Copyright © 2007 John Wiley & Sons, Ltd.