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Complexation study of midazolam hydrochloride with β-cyclodextrin: NMR spectroscopic study in solution

✍ Scribed by Syed Mashhood Ali; Santosh Kumar Upadhyay

Publisher
John Wiley and Sons
Year
2008
Tongue
English
Weight
240 KB
Volume
46
Category
Article
ISSN
0749-1581

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✦ Synopsis

Abstract

^1^H NMR spectroscopic study of midazolam hydrochloride (MDL), β‐cyclodextrin (β‐CD) and their mixtures confirmed the formation of β‐CD‐MDL inclusion complex in aqueous solution. The stoichiometry of the complexes was determined by Scott's method to be 1:1, and the association constant (K~a~) was calculated to be 108 M^−1^. It was confirmed on the basis of 2D ROESY spectral data that only a fluorine‐substituted aromatic ring acted as guest in complexation. Most of the aromatic signals of MDL exhibited induced shift changes as well as splitting, in the presence of β‐CD, indicating chiral differentiation of MDL by β‐CD. Copyright © 2008 John Wiley & Sons, Ltd.

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