Efficient synthesis of primary 2-aminothiols from 2-aminoalcohols and methyldithioacetate
✍ Scribed by Guillaume Mercey; Delphine Brégeon; Annie-Claude Gaumont; Jocelyne Levillain; Mihaela Gulea
- Book ID
- 104095798
- Publisher
- Elsevier Science
- Year
- 2008
- Tongue
- French
- Weight
- 154 KB
- Volume
- 49
- Category
- Article
- ISSN
- 0040-4039
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## Abstract magnified image Condensation of aminoalcohols with 2‐HC(O)C~6~H~4~B(OH)~2~ afforded the macrocyclic compounds 1–7 with an OBOBO structural unit. Crystals of **1** were triclinic, space group P‐1, a = 9.9818(12) Å, b = 12.8302(15) Å, c = 13.1663(15) Å, α = 105.503(2)°, β = 94.860(2)°, γ
Substituted imidazoles can be prepared efficiently from cyclic or acyclic 1,2-aminoalcohols via a four-step procedure involving acylation of the amine, oxidation of the alcohol, imine formation and cyclization. Examples are presented and the methodology is applied in the generation of a library of c
## Abstract For Abstract see ChemInform Abstract in Full Text.