Parallel synthesis of substituted imidazoles from 1,2-aminoalcohols

✍ Scribed by Konrad H. Bleicher; Fernand Gerber; Yves Wüthrich; Alexander Alanine; Alfredo Capretta

• Publisher: Elsevier Science
• Year: 2002
• Tongue: French
• Weight: 191 KB
• Volume: 43
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(02)01839-7

✦ Synopsis

Substituted imidazoles can be prepared efficiently from cyclic or acyclic 1,2-aminoalcohols via a four-step procedure involving acylation of the amine, oxidation of the alcohol, imine formation and cyclization. Examples are presented and the methodology is applied in the generation of a library of compounds containing a fused imidazole-azepine motif.