The cytotoxicities of the a-methylidene-g-butyrolactones 4, 5, and 8, which are linked to a quinolin-4(1H)one moiety through a piperazine or O-atom bridge were studied. These compounds were synthesized by alkylation of 1-ethyl-6-fluoro-1,4-dihydro-7-hydroxy-4-oxoquinoline-3-carboxylic acid (6) follo
Efficient Synthesis and Cytotoxic Activity of Some Symmetrical Disulfides Derived from the Quinolin-4(1H)-one Skeleton
✍ Scribed by Miroslav Soural; Jan Hlaváč; Pavel Hradil; Marián Hajdúch
- Book ID
- 102171387
- Publisher
- John Wiley and Sons
- Year
- 2009
- Tongue
- English
- Weight
- 162 KB
- Volume
- 2009
- Category
- Article
- ISSN
- 1434-193X
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## Abstract As part of our ongoing research effort to develop new antimitotic agents based on the recently reported pyrimido[4,5‐__c__]quinoline‐1(2__H__)‐one ring skeleton, we were interested in identifying structural elements that contribute to the cytotoxicity of this class of compounds. The eff
The coordination behaviour of the diorganotin(1V) compounds R,SnCI, (where R = Me, Ph) with 4Hpyrido [ 1,2-a] pyrimidin-4-one derivatives (L) has been described. The complexes R,SnCI,. L obtained have been characterized physicochemically and spectroscopically. The pyrimidin-Cone ligands were found t
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