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Synthesis, characterization and cytotoxic activity of diorganotin (IV) complexes with 4H-pyrido[1,2-a]pyrimidin-4-one derivatives

✍ Scribed by Talal A.K. Al-Allaf; Redha I.H. Al-Bayati; Luay J. Rashan; Rula F. Khuzaie

Publisher: John Wiley and Sons
Year: 1996
Tongue: English
Weight: 376 KB
Volume: 10
Category: Article
ISSN: 0268-2605
DOI: 10.1002/(sici)1099-0739(199602)10:1<47::aid-aoc476>3.0.co;2-3

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✦ Synopsis

The coordination behaviour of the diorganotin(1V) compounds R,SnCI, (where R = Me, Ph) with 4Hpyrido [ 1,2-a] pyrimidin-4-one derivatives (L) has been described. The complexes R,SnCI,. L obtained have been characterized physicochemically and spectroscopically. The pyrimidin-Cone ligands were found to coordinate with R,SnCl, species in a monodentate fashion, mainly via the oxygen atom of the 4-one group or possibly via the nitrogen atom of the -C=N linkage (the less sterically hindered nitrogen of the pyrimidine derivative) to give pentacoordinate tin complexes. Of the complexes selected to be screened against five tumour cell lines, some exhibited significant in uitro activity.

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