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Synthesis, characterization and cytotoxic activity of complexes of diorganotin(IV) halides with N-methyl-2,2′-bisimidazole

✍ Scribed by P. Alvarez Boo; J. S. Casas; M. D. Couce; E. Freijanes; A. Furlani; V. Scarcia; J. Sordo; U. Russo; M. Varela

Publisher
John Wiley and Sons
Year
1997
Tongue
English
Weight
121 KB
Volume
11
Category
Article
ISSN
0268-2605

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✦ Synopsis

The compounds [SnR 2 X 2 (MBIm)] (MBIm = Nmethyl-2,2Ј-bisimidazole; R = Me, Et, Bu, Ph; X = Cl or Br) have been synthesized and characterized by IR, Raman, Mössbauer and NMR spectroscopy, and their capacity to inhibit tumour cell division has been assayed. Measurements of conductivity in acetonitrile show the adducts to behave as non-ionogens in this solvent. The IR, Raman and Mössbauer data suggest that all the complexes have analogous pseudo-octahedral coordination geometries, with the R groups trans and MBIm bidentate. The 1 H NMR spectra show the MBIm ligand to be partially dissociated in CDCl 3 . The most active compounds against the established cell line KB were the butyl derivatives.

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