Synthesis and Cytotoxic Activities of α-
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Shu-Lin Hsu; Yeh-Long Chen; Cherng-Chyi Tzeng; Kuo-Chang Fang; Jia-Yuh Sheu
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Article
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2001
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John Wiley and Sons
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German
⚖ 80 KB
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The cytotoxicities of the a-methylidene-g-butyrolactones 4, 5, and 8, which are linked to a quinolin-4(1H)one moiety through a piperazine or O-atom bridge were studied. These compounds were synthesized by alkylation of 1-ethyl-6-fluoro-1,4-dihydro-7-hydroxy-4-oxoquinoline-3-carboxylic acid (6) follo