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ChemInform Abstract: α-Methylidene-γ-butyrolactones: Synthesis and Evaluation of Quinolin-2(1H)-one Derivatives.

✍ Scribed by T.-C. WANG; Y.-L. CHEN; C.-C. TZENG; S.-S. LIOU; W.-F. TZENG; Y.-L. CHANG; C.-M. TENG


Publisher
John Wiley and Sons
Year
2010
Weight
37 KB
Volume
29
Category
Article
ISSN
0931-7597

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The cytotoxicities of the a-methylidene-g-butyrolactones 4, 5, and 8, which are linked to a quinolin-4(1H)one moiety through a piperazine or O-atom bridge were studied. These compounds were synthesized by alkylation of 1-ethyl-6-fluoro-1,4-dihydro-7-hydroxy-4-oxoquinoline-3-carboxylic acid (6) follo