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Synthesis and Antiplatelet-Activity Evaluation of α-Methylidene-γ-butyrolactones Bearing 3,4-Dihydroquinolin-2(1H)-one Moieties

✍ Scribed by Cherng-Chyi Tzeng; I.-Li Chen; Yeh-Long Chen; Tai-Chi Wang; Ya-Ling Chang; Che-Ming Teng


Publisher
John Wiley and Sons
Year
2000
Tongue
German
Weight
128 KB
Volume
83
Category
Article
ISSN
0018-019X

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✍ Shu-Lin Hsu; Yeh-Long Chen; Cherng-Chyi Tzeng; Kuo-Chang Fang; Jia-Yuh Sheu 📂 Article 📅 2001 🏛 John Wiley and Sons 🌐 German ⚖ 80 KB

The cytotoxicities of the a-methylidene-g-butyrolactones 4, 5, and 8, which are linked to a quinolin-4(1H)one moiety through a piperazine or O-atom bridge were studied. These compounds were synthesized by alkylation of 1-ethyl-6-fluoro-1,4-dihydro-7-hydroxy-4-oxoquinoline-3-carboxylic acid (6) follo