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Synthesis and Cytotoxicity Evaluation of Certain α-Methylidene- γ-butyrolactones Bearing Coumarin, Flavone, Xanthone, Carbazole, and Dibenzofuran Moieties

✍ Scribed by Yeh-Long Chen; I-Li Chen; Cherng-Chyi Tzeng; Tai-Chi Wang

Publisher
John Wiley and Sons
Year
2000
Tongue
German
Weight
108 KB
Volume
83
Category
Article
ISSN
0018-019X

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Synthesis and Cytotoxic Activities of α-Methylidene-γ-butyrolactones Bearing a Quinolin-4(1H)-one Moiety
✍ Shu-Lin Hsu; Yeh-Long Chen; Cherng-Chyi Tzeng; Kuo-Chang Fang; Jia-Yuh Sheu 📂 Article 📅 2001 🏛 John Wiley and Sons 🌐 German ⚖ 80 KB

The cytotoxicities of the a-methylidene-g-butyrolactones 4, 5, and 8, which are linked to a quinolin-4(1H)one moiety through a piperazine or O-atom bridge were studied. These compounds were synthesized by alkylation of 1-ethyl-6-fluoro-1,4-dihydro-7-hydroxy-4-oxoquinoline-3-carboxylic acid (6) follo