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Pyrimido[4,5-c]quinolin-1(2H)-ones as a Novel Class of Antimitotic Agents: Synthesis and in vitro Cytotoxic Activity.

✍ Scribed by Kamel Metwally; Harris Pratsinis; Dimitris Kletsas

Publisher
John Wiley and Sons
Year
2007
Weight
28 KB
Volume
38
Category
Article
ISSN
0931-7597

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✦ Synopsis

Abstract

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Synthesis, in-vitro Cytotoxicity, and a
Synthesis, in-vitro Cytotoxicity, and a Preliminary Structure-Activity Relationship Investigation of Pyrimido[4,5-c]quinolin-1(2H)-ones
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## Abstract As part of our ongoing research effort to develop new antimitotic agents based on the recently reported pyrimido[4,5‐__c__]quinoline‐1(2__H__)‐one ring skeleton, we were interested in identifying structural elements that contribute to the cytotoxicity of this class of compounds. The eff

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## Abstract The effect of various electron‐withdrawing halo substituents is studied using analogues such as (VIb), (VId), and (VIe), whereas the derivatives (VIa) and (VIc) enable the investigation of electron‐donating substituents.

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## Abstract Efficient and direct protocols for the regioselective synthesis of the title compounds (IV) and (IX), resp., using multicomponent reactions of 5‐aminouracil (II) are given.