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ChemInform Abstract: Synthesis, in vitro Cytotoxicity, and a Preliminary Structure—Activity Relationship Investigation of Pyrimido[4,5-c]quinolin-1(2H)-ones.

✍ Scribed by Kamel Metwally; Ashraf Khalil; Harris Pratsinis; Dimitris Kletsas

Publisher: John Wiley and Sons
Year: 2010
Weight: 34 KB
Volume: 41
Category: Article
ISSN: 0931-7597
DOI: 10.1002/chin.201051165

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✦ Synopsis

Abstract

The effect of various electron‐withdrawing halo substituents is studied using analogues such as (VIb), (VId), and (VIe), whereas the derivatives (VIa) and (VIc) enable the investigation of electron‐donating substituents.

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Synthesis, in-vitro Cytotoxicity, and a

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## Abstract As part of our ongoing research effort to develop new antimitotic agents based on the recently reported pyrimido[4,5‐__c__]quinoline‐1(2__H__)‐one ring skeleton, we were interested in identifying structural elements that contribute to the cytotoxicity of this class of compounds. The eff

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## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.

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