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Synthesis and Structure–Activity Relationships of 1-Benzyl-4,5,6-trimethoxyindoles as a Novel Class of Potent Antimitotic Agents

✍ Scribed by Mei-Jung Lai; Ching-Chuan Kuo; Teng-Kuang Yeh; Hsing-Pang Hsieh; Li-Tzong Chen; Wen-Yu Pan; Kuang-Yang Hsu; Jang-Yang Chang; Jing-Ping Liou


Publisher
John Wiley and Sons
Year
2009
Tongue
English
Weight
241 KB
Volume
4
Category
Article
ISSN
1860-7179

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Synthesis and Structure-Activity Relatio
✍ Xueling Hou; Zemei Ge; Tingmin Wang; Wei Guo; Jun Wu; Jingrong Cui; Chingsan Lai 📂 Article 📅 2011 🏛 John Wiley and Sons 🌐 English ⚖ 490 KB 👁 2 views

## Abstract Based on a novel lead compound 4‐methylpiperazine‐1‐carbodithioic acid 3‐cyano‐3,3‐diphenylpropyl ester **1**, the systematic structural modification was carried out. All the synthesized compounds were evaluated for their __in‐vitro__ anticancer activities on four to six different cell