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Efficient preparation of carbohydrate–oligonucleotide conjugates (COCs) using oxime bond formation

✍ Scribed by Damien Forget; Olivier Renaudet; Eric Defrancq; Pascal Dumy

Book ID
104231730
Publisher
Elsevier Science
Year
2001
Tongue
French
Weight
156 KB
Volume
42
Category
Article
ISSN
0040-4039

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✦ Synopsis

Chemoselective ligation of carbohydrates to oligonucleotides was accomplished by oxime bond formation. The conjugation was performed by reacting an oxyamino sugar with an oligonucleotide containing an aldehyde moiety at the 5%-end. The carbohydrate-oligonucleotide conjugates (COCs) were obtained in good yield without the need of a protection strategy and under mild aqueous conditions.

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