A convergent strategy for the synthesis of peptide ± oligonucleotide conjugates (POC) is presented. Chemoselective ligation of peptide to oligonucleotide was accomplished by oxime and thiazolidine formation. Oxime conjugation was performed by treating an oxyamine-containing peptide with an aldehyde-
✦ LIBER ✦
Highly Efficient Synthesis of Peptide- and Carbohydrate-Oligonucleotide Conjugates Using Chemoselective Oxime and Thiazolidine Formation
✍ Scribed by D. Forget; D. Boturyn; O. Renaudet; E. Defrancq; P. Dumy
- Publisher
- John Wiley and Sons
- Year
- 2004
- Weight
- 61 KB
- Volume
- 35
- Category
- Article
- ISSN
- 0931-7597
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