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Highly Efficient Synthesis of Peptide- and Carbohydrate-Oligonucleotide Conjugates Using Chemoselective Oxime and Thiazolidine Formation

✍ Scribed by D. Forget; D. Boturyn; O. Renaudet; E. Defrancq; P. Dumy


Publisher
John Wiley and Sons
Year
2004
Weight
61 KB
Volume
35
Category
Article
ISSN
0931-7597

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Highly Efficient Synthesis of Peptide–Ol
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A convergent strategy for the synthesis of peptide ± oligonucleotide conjugates (POC) is presented. Chemoselective ligation of peptide to oligonucleotide was accomplished by oxime and thiazolidine formation. Oxime conjugation was performed by treating an oxyamine-containing peptide with an aldehyde-

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