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ChemInform Abstract: Highly Efficient Synthesis of Peptide — Oligonucleotide Conjugates: Chemoselective Oxime and Thiazolidine Formation.

✍ Scribed by Damien Forget; Didier Boturyn; Eric Defrancq; Jean Lhomme; Pascal Dumy

Publisher
John Wiley and Sons
Year
2010
Weight
25 KB
Volume
33
Category
Article
ISSN
0931-7597

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Highly Efficient Synthesis of Peptide–Ol
Highly Efficient Synthesis of Peptide–Oligonucleotide Conjugates: Chemoselective Oxime and Thiazolidine Formation
✍ Damien Forget; Didier Boturyn; Eric Defrancq; Jean Lhomme; Pascal Dumy 📂 Article 📅 2001 🏛 John Wiley and Sons 🌐 English ⚖ 162 KB

A convergent strategy for the synthesis of peptide ± oligonucleotide conjugates (POC) is presented. Chemoselective ligation of peptide to oligonucleotide was accomplished by oxime and thiazolidine formation. Oxime conjugation was performed by treating an oxyamine-containing peptide with an aldehyde-

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