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Efficient and versatile synthesis of a-ring precursors of 1α,25-dihydroxy-vitamin D3 and analogues. Application to the synthesis of Lythgoe-Roche phosphine oxide

✍ Scribed by Antonio Mouriño; Mercedes Torneiro; Cristian Vitale; Sara Fernández; José Pérez-Sestelo; Sofia Anné; Carlos Gregorio

Publisher: Elsevier Science
Year: 1997
Tongue: French
Weight: 202 KB
Volume: 38
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(97)01005-8

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✦ Synopsis

An efficient, versatile synthesis of Lythgoe-Phosphine Oxide has been developed starting from /-carvone. The key steps are rupture of protected epoxide 7 to give dicarbonyl compound 8, preparation of vinylic triflate 2, and palladium-catalysed cyclization-carbonylation of vinylic triflate 2.

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