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Efficacy of antiepileptic tetramethylcyclopropyl analogues of valproic acid amides in a rat model of neuropathic pain

โœ Scribed by Ilan Winkler; Eyal Sobol; Boris Yagen; Amir Steinman; Marshall Devor; Meir Bialer

Book ID
116784404
Publisher
Elsevier Science
Year
2005
Tongue
English
Weight
338 KB
Volume
49
Category
Article
ISSN
0028-3908

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Tetramethylcyclopropyl analogue of the leading antiepileptic drug, valproic acid: Evaluation of the teratogenic effects of its amide derivatives in NMRI mice
โœ Akinobu Okada; Yuko Onishi; Boris Yagen; Jakob Avi Shimshoni; Dan Kaufmann; Meir ๐Ÿ“‚ Article ๐Ÿ“… 2008 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 328 KB ๐Ÿ‘ 2 views

## Abstract **BACKGROUND:** Although valproic acid (VPA) is used extensively for treating various kinds of epilepsy, it causes hepatotoxicity and teratogenicity. In an attempt to develop a more potent and safer second generation to VPA drug, the amide derivatives of the tetramethylcyclopropyl VPA a