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A novel benzazepinone sodium channel blocker with oral efficacy in a rat model of neuropathic pain

โœ Scribed by Hoyt, Scott B.; London, Clare; Abbadie, Catherine; Felix, John P.; Garcia, Maria L.; Jochnowitz, Nina; Karanam, Bindhu V.; Li, Xiaohua; Lyons, Kathryn A.; McGowan, Erin; Priest, Birgit T.; Smith, McHardy M.; Warren, Vivien A.; Thomas-Fowlkes, Brande S.; Kaczorowski, Gregory J.; Duffy, Joseph L.


Book ID
120588272
Publisher
Elsevier Science
Year
2013
Tongue
English
Weight
914 KB
Volume
23
Category
Article
ISSN
0960-894X

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A series of novel biphenyl pyrazole dicarboxamides were identified as potential sodium channel blockers for treatment of neuropathic pain. Compound 20 had outstanding efficacy in the Chung rat spinal nerve ligation (SNL) model of neuropathic pain.