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Discovery of a novel class of biphenyl pyrazole sodium channel blockers for treatment of neuropathic pain

✍ Scribed by Sriram Tyagarajan; Prasun K. Chakravarty; Bishan Zhou; Brett Taylor; Ronsar Eid; Michael H. Fisher; William H. Parsons; Mathew J. Wyvratt; Kathryn A. Lyons; Tracy Klatt; Xiaohua Li; Sanjeev Kumar; Brande Williams; John Felix; Birgit T. Priest; Richard M. Brochu; Vivien Warren; McHardy Smith; Maria Garcia; Gregory J. Kaczorowski; William J. Martin; Catherine Abbadie; Erin McGowan; Nina Jochnowitz; Ann Weber; Joseph L. Duffy

Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
444 KB
Volume
20
Category
Article
ISSN
0960-894X

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✦ Synopsis

A series of novel biphenyl pyrazole dicarboxamides were identified as potential sodium channel blockers for treatment of neuropathic pain. Compound 20 had outstanding efficacy in the Chung rat spinal nerve ligation (SNL) model of neuropathic pain.

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