✦ LIBER ✦

Tetramethylcyclopropyl Analogue of a Leading Antiepileptic Drug, Valproic Acid. Synthesis and Evaluation of Anticonvulsant Activity of Its Amide Derivatives

✍ Scribed by Sobol, Eyal; Bialer, Meir; Yagen, Boris

Book ID: 115511990
Publisher: American Chemical Society
Year: 2004
Tongue: English
Weight: 401 KB
Volume: 47
Category: Article
ISSN: 0022-2623
DOI: 10.1021/jm0498351

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

Tetramethylcyclopropyl analogue of the l

Tetramethylcyclopropyl analogue of the leading antiepileptic drug, valproic acid: Evaluation of the teratogenic effects of its amide derivatives in NMRI mice

✍ Akinobu Okada; Yuko Onishi; Boris Yagen; Jakob Avi Shimshoni; Dan Kaufmann; Meir 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 English ⚖ 328 KB 👁 2 views

## Abstract **BACKGROUND:** Although valproic acid (VPA) is used extensively for treating various kinds of epilepsy, it causes hepatotoxicity and teratogenicity. In an attempt to develop a more potent and safer second generation to VPA drug, the amide derivatives of the tetramethylcyclopropyl VPA a

Synthesis and anticonvulsant evaluation

Synthesis and anticonvulsant evaluation of dimethylethanolamine analogues of valproic acid and its tetramethylcyclopropyl analogue

✍ Tawfeeq Shekh-Ahmad; Meir Bialer; Eylon Yavin 📂 Article 📅 2012 🏛 Elsevier Science 🌐 English ⚖ 583 KB

Synthesis and Evaluation of Antiallodyni

Synthesis and Evaluation of Antiallodynic and Anticonvulsant Activity of Novel Amide and Urea Derivatives of Valproic Acid Analogues

✍ Kaufmann, Dan; Bialer, Meir; Shimshoni, Jakob Avi; Devor, Marshall; Yagen, Boris 📂 Article 📅 2009 🏛 American Chemical Society 🌐 English ⚖ 999 KB

Synthesis of GABA-Valproic Acid Derivati

Synthesis of GABA-Valproic Acid Derivatives and Evaluation of Their Anticonvulsant and Antioxidant Activity

✍ George V. Rekatas; Ekaterini Tani; Vassilis J. Demopoulos; Panos N. Kourounakis 📂 Article 📅 1996 🏛 John Wiley and Sons 🌐 English ⚖ 582 KB

Synthesis, structural analysis and antic

Synthesis, structural analysis and anticonvulsant activity of a ternary Cu(II) mononuclear complex containing 1,10-phenanthroline and the leading antiepileptic drug valproic acid

✍ Maité Sylla-Iyarreta Veitía; Françoise Dumas; Georges Morgant; John R.J. Sorenso 📂 Article 📅 2009 🏛 Elsevier Science 🌐 English ⚖ 341 KB

Anticonvulsant profile and teratogenic e

Anticonvulsant profile and teratogenic evaluation of potent new analogues of a valproic acid urea derivative in NMRI mice

✍ Akinobu Okada; Hiroko Noyori; Boris Yagen; Jakob Avi Shimshoni; Meir Bialer; Mic 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 116 KB 👁 1 views