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Synthesis and anticonvulsant evaluation of dimethylethanolamine analogues of valproic acid and its tetramethylcyclopropyl analogue

โœ Scribed by Tawfeeq Shekh-Ahmad; Meir Bialer; Eylon Yavin


Book ID
113606323
Publisher
Elsevier Science
Year
2012
Tongue
English
Weight
583 KB
Volume
98
Category
Article
ISSN
0920-1211

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Tetramethylcyclopropyl analogue of the l
โœ Akinobu Okada; Yuko Onishi; Boris Yagen; Jakob Avi Shimshoni; Dan Kaufmann; Meir ๐Ÿ“‚ Article ๐Ÿ“… 2008 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 328 KB ๐Ÿ‘ 2 views

## Abstract **BACKGROUND:** Although valproic acid (VPA) is used extensively for treating various kinds of epilepsy, it causes hepatotoxicity and teratogenicity. In an attempt to develop a more potent and safer second generation to VPA drug, the amide derivatives of the tetramethylcyclopropyl VPA a