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Anticonvulsant and neurotoxic activities of twelve analogues of valproic acid

✍ Scribed by M. M. A. Elmazar; R.-S. Hauck; H. Nau


Publisher
John Wiley and Sons
Year
1993
Tongue
English
Weight
513 KB
Volume
82
Category
Article
ISSN
0022-3549

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πŸ“œ SIMILAR VOLUMES


Pharmacokinetic analysis and anticonvuls
✍ Salim Hadad; Tom B. Vree; Eppo Van Der Kleijn; Meir Bialer πŸ“‚ Article πŸ“… 1993 πŸ› John Wiley and Sons 🌐 English βš– 464 KB πŸ‘ 2 views

## Abstract The pharmacokinetics of the following two polyesteric prodrugs of valproic acid (VPA) have been investigated: 1,4‐butanediol divaiproate (BDV) and glyceryl trivalproate (GTV). In addition, the anticonvulsant activity of these compounds has been evaluated and compared to that of VPA and

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Propylisopropyl acetamide (PID), an amide analogue of the major antiepileptic drug valproic acid (VPA), possesses favorable anticonvulsant and CNS properties. PID contains one chiral carbon atom and therefore exists in two enantiomeric forms. The purpose of this work was to synthesize the two PID en