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Effects on the Pharmacokinetics and Pharmacodynamics in the Elderly of Coadministering Ramipril with Water, Apple Juice, and Applesauce

โœ Scribed by I-Der Lee; Thomas L. Hunt; Charles R. Bradley; Carol Copp; Lynne Griffiths; Joyce Brobst-Kromer


Book ID
110344157
Publisher
Springer US
Year
1996
Tongue
English
Weight
692 KB
Volume
13
Category
Article
ISSN
0724-8741

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The effects of temporary water deprivation for 48 h on the pharmacokinetics and pharmacodynamics of bumetanide were examined after intravenous (i.v.) administration of bumetanide, 8mg kg-' to control and water deprived rats (n=7). The values of AUC, t,,, and MRT increased 79.0, 417, and 633 per cent